Network dynamics of hypothalamic feeding neurons
نویسندگان
چکیده
منابع مشابه
Network of hypothalamic neurons that control appetite
The central nervous system (CNS) controls food intake and energy expenditure via tight coordinations between multiple neuronal populations. Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetite-increasing) neuropeptide Y (NPY)/agouti-related pept...
متن کاملHypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which...
متن کاملVENTROMEDIAL HYPOTHALAMIC NUCLEI AND FEEDING BEHAVIOR
The role of the ventromedial nuclei of the hypothalamus (VMN) in food behavior was studied in adult male rats, allocated in 3 groups: control, sham and lesioned. Electrolytic lesions were induced stereotaxically (1.2 mA, 15 sec). Results revealed a significant decrease (p<O.05) in body weight (BW) and food intake (FI) in the order of lesioned <sham <control during the fIrst week. However, ...
متن کاملActivity of Single Neurons in the Hypothalamic Feeding Centers: Effect of Glucose.
ANAND, B. K.,G. S. CHHINA, K.N. SHARMA, S. DUA, AND BALDEV SINGH. Activity of single neurons in the hypothalamic feeding centers: effect of glucose. Am. J. Physiol. 207(s): I 146-1154. I g6+-Unit activity from neurons of hypothalamic feeding and satiety mechanisms, and from adjacent hypothalamic regions was recorded in anesthetized dogs with surgically exposed hypothalamus, and in Flaxedil-immo...
متن کاملHypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons
Activation of orexigenic AgRP-expressing neurons in the arcuate nucleus of the hypothalamus potently promotes feeding, thus defining new regulators of AgRP neuron activity could uncover potential novel targets for obesity treatment. Here, we demonstrate that AgRP neurons express the purinergic receptor 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK phosphory...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2021
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2011140118